Asymmetric [ 3 H]‐labeling using ruthenium catalyzed transfer hydrogenation | Zendy

Arns Steve | Zendy; Moreau Anne | Zendy; Young Robert N. | Zendy

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Asymmetric [ 3 H]‐labeling using ruthenium catalyzed transfer hydrogenation

Author(s) -

Arns Steve,

Moreau Anne,

Young Robert N.

Publication year - 2010

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1753

Subject(s) - chemistry , ruthenium , enantioselective synthesis , catalysis , transfer hydrogenation , tritium , prostaglandin , combinatorial chemistry , organic chemistry , biochemistry , physics , nuclear physics

The first general method for asymmetric tritiation using ruthenium catalyzed transfer hydrogenation and its application to the radiosynthesis of an exemplary prostaglandin EP4 receptor‐selective Prostaglandin E 2 analog is described. The methodology should be of general utility for the enantioselective preparation of α‐tritiated chiral secondary alcohols. Copyright © 2010 John Wiley & Sons, Ltd.

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