Premium
Asymmetric [ 3 H]‐labeling using ruthenium catalyzed transfer hydrogenation
Author(s) -
Arns Steve,
Moreau Anne,
Young Robert N.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1753
Subject(s) - chemistry , ruthenium , enantioselective synthesis , catalysis , transfer hydrogenation , tritium , prostaglandin , combinatorial chemistry , organic chemistry , biochemistry , physics , nuclear physics
The first general method for asymmetric tritiation using ruthenium catalyzed transfer hydrogenation and its application to the radiosynthesis of an exemplary prostaglandin EP4 receptor‐selective Prostaglandin E 2 analog is described. The methodology should be of general utility for the enantioselective preparation of α‐tritiated chiral secondary alcohols. Copyright © 2010 John Wiley & Sons, Ltd.