Novel synthesis of [ 13 C 4 , 15 N]1H‐pyrrole‐2,3,5‐tricarboxylic acid: an important biomarker for melatonin metabolism | Zendy

Skaddan Marc B. | Zendy

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Novel synthesis of [ 13 C 4 , 15 N]1H‐pyrrole‐2,3,5‐tricarboxylic acid: an important biomarker for melatonin metabolism

Author(s) -

Skaddan Marc B.

Publication year - 2010

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1704

Subject(s) - chemistry , tricarboxylic acid , citric acid cycle , pyrrole , yield (engineering) , metabolism , chemical synthesis , biochemistry , combinatorial chemistry , organic chemistry , in vitro , materials science , metallurgy

1H‐pyrrole‐2,3,5‐tricarboxylic acid is a breakdown product of melatonin. A labeled version of this compound would serve as a key biomarker for drug candidates which track this substance to monitor their effectiveness (e.g. hyperpigmentation drugs). A Hantzsch synthesis using readily available starting materials was used to generate [ 13 C 4 , 15 N]1H‐pyrrole‐2,3,5‐tricarboxylic acid in six steps (12% overall yield). Copyright © 2009 John Wiley & Sons, Ltd.

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