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Cigarettes labeled with [ 11 C]nicotine: formulation and administration for PET inhalation
Author(s) -
Apana S. M.,
Berridge M. S.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1692
Subject(s) - nicotine , chemistry , inhalation , biodistribution , positron emission tomography , bolus (digestion) , pharmacology , nicotine addiction , addiction , sensitization , anesthesia , nuclear medicine , medicine , psychology , psychiatry , neuroscience , biochemistry , in vitro
The ultimate goal of this work was to relate nicotine kinetics in the brain after cigarette smoking to a feature of sensitization in drug addiction. To do this required a positron emission tomography study to measure the regional cerebral biodistribution kinetics of cigarette‐smoked nicotine. This in turn required a cigarette formulated with carbon‐11 labeled nicotine suitable for administration by single bolus inhalation. Here we report the development and validation of cigarettes formulated with [ 11 C]nicotine that were successfully used for single bolus administration by smoking. We also report measurements of nicotine delivery from smoked cigarettes. Copyright © 2009 John Wiley & Sons, Ltd.