Cigarettes labeled with [ 11 C]nicotine: formulation and administration for PET inhalation | Zendy

Apana S. M. | Zendy; Berridge M. S. | Zendy

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Cigarettes labeled with [ 11 C]nicotine: formulation and administration for PET inhalation

Author(s) -

Apana S. M.,

Berridge M. S.

Publication year - 2010

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1692

Subject(s) - nicotine , chemistry , inhalation , biodistribution , positron emission tomography , bolus (digestion) , pharmacology , nicotine addiction , addiction , sensitization , anesthesia , nuclear medicine , medicine , psychology , psychiatry , neuroscience , biochemistry , in vitro

The ultimate goal of this work was to relate nicotine kinetics in the brain after cigarette smoking to a feature of sensitization in drug addiction. To do this required a positron emission tomography study to measure the regional cerebral biodistribution kinetics of cigarette‐smoked nicotine. This in turn required a cigarette formulated with carbon‐11 labeled nicotine suitable for administration by single bolus inhalation. Here we report the development and validation of cigarettes formulated with [ 11 C]nicotine that were successfully used for single bolus administration by smoking. We also report measurements of nicotine delivery from smoked cigarettes. Copyright © 2009 John Wiley & Sons, Ltd.

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