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Synthesis and elucidation of deuterated vanillylamine hydrochloride and capsaicin
Author(s) -
Kim Sang Wook,
Park Jeong Hoon,
Jung Soon Jae,
Choi Tae Bum,
Hur Min Goo,
Yang Seung Dae,
Yu Kook Hyun
Publication year - 2009
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1678
Subject(s) - capsaicin , chemistry , biosynthesis , hydrochloride , stereochemistry , deuterium , biochemistry , enzyme , receptor , physics , quantum mechanics
Capsaicin is the major pungent component of hot peppers, which belong to the plant genus Capsicum . Although the biosynthesis of capsaicin is known to involve the condensation of vanillylamine and 8‐methylnonenoic acid by capsaicin synthase, the mechanism of biosynthesis is still not fully understood. In this study, deuterium labelled versions of capsaicin and the precursor vanillylamine were synthesized in order to investigate the biosynthesis of capsaicin in hot peppers. Copyright © 2009 John Wiley & Sons, Ltd.