Synthesis of deuterium labelled diclofenac with improved isotopic enrichment | Zendy

Wu Keying | Zendy; Tian Lei | Zendy; Li Hongye | Zendy; Li Jian | Zendy; Chen Liqin | Zendy

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Synthesis of deuterium labelled diclofenac with improved isotopic enrichment

Author(s) -

Wu Keying,

Tian Lei,

Li Hongye,

Li Jian,

Chen Liqin

Publication year - 2009

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1669

Subject(s) - chemistry , deuterium , diclofenac , acetic acid , metabolite , radiochemistry , organic chemistry , biochemistry , physics , quantum mechanics

A five‐step synthesis of deuterium‐labelled diclofenac starting from 2‐phenyl[ 2 H 5 ] acetic acid is described. The synthesis prevents deuterium from scrambling during the reaction. It offers the labelled compound with over 99% isotopic enrichment. It also provides a possible alternative route for the synthesis of deuterium‐labelled 4′‐hydroxydiclofenac, which is the principal human metabolite of diclofenac. Copyright © 2009 John Wiley & Sons, Ltd.

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