[ 14 C]Dimethyltitanocene and [ 14 C]Methyl(methyltrimethylsilyl) titanocene–Reagents for the [ 14 C]olefination of carbonyl compounds: synthesis of [ 14 C]Aprepitant | Zendy

Wallace M. A. | Zendy; Dean D. C. | Zendy; Melillo D. G. | Zendy

Premium

[ 14 C]Dimethyltitanocene and [ 14 C]Methyl(methyltrimethylsilyl) titanocene–Reagents for the [ 14 C]olefination of carbonyl compounds: synthesis of [ 14 C]Aprepitant

Author(s) -

Wallace M. A.,

Dean D. C.,

Melillo D. G.

Publication year - 2009

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1667

Subject(s) - aprepitant , chemistry , reagent , methyllithium , antagonist , stereochemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry , medicine , surgery , antiemetic , vomiting

A neurokinin (NK‐1) receptor antagonist, [ 14 C]Aprepitant, was synthesized using two labeled olefination reagents: [ 14 C]dimethyltitanocene 1 and [ 14 C]methyl (methyltrimethylsilyl)titanocene 7. Both reagents can be readily prepared from [ 14 C]methyllithium and have been shown to convert a variety of carbonyls to [ 14 C]methylenes in good radiochemical yields. Copyright © 2009 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research