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Utility of commercial radiosynthetic modules in captive solvent [ 11 C]‐methylation reactions
Author(s) -
Wilson Alan A.,
Garcia Armando,
Houle Sylvain,
Vasdev Neil
Publication year - 2009
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1618
Subject(s) - chemistry , methylation , solvent , radiochemistry , organic chemistry , biochemistry , gene
The utility of commercial radiosynthetic modules to prepare [ 11 C]‐radiotracers using the captive solvent ‘LOOP’ method is demonstrated with the common radiosynthons [ 11 C]‐iodomethane and [ 11 C]‐methyl triflate. Several widely utilized radiotracers are prepared by this technique to demonstrate the versatility of the method. Copyright © 2009 John Wiley & Sons, Ltd.
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