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Deuterium labelling of theaflavin
Author(s) -
Peng Weimin,
Yao Yinfang
Publication year - 2009
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1605
Subject(s) - chemistry , theaflavin , labelling , deuterium , nuclear magnetic resonance spectroscopy , stereochemistry , polyphenol , combinatorial chemistry , organic chemistry , biochemistry , antioxidant , physics , quantum mechanics
An efficient deuterium labelling of theaflavin, aiming at radiolabelling of theaflavin, was accomplished for the first time by using 4‐deuterium‐labelled epi ‐catechin as the precursor and the resulting D ‐labelled theaflavin was fully characterized by 1 H NMR, 13 C NMR, IR spectroscopy and ESI‐MS. The synthesis features a novel efficient polyphenol oxidase (PPO) catalyzed benzotropolone formation. PPO was bound onto a selected polymer by a novel efficient method developed in this lab. Copyright © 2009 John Wiley & Sons, Ltd.