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Alternative solvents for electrophilic synthesis of 6‐[ 18 F]fluoro‐ L ‐DOPA
Author(s) -
Forsback Sarita,
Eskola Olli,
Bergman Jörgen,
Haaparanta Merja,
Solin Olof
Publication year - 2009
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1599
Subject(s) - chemistry , electrophile , dichloromethane , yield (engineering) , acetic acid , acetone , chloroform , freon , radiochemistry , deuterium , organic chemistry , nuclear chemistry , solvent , materials science , physics , quantum mechanics , metallurgy , catalysis
Owing to the ozone layer‐depleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freon‐11 in the electrophilic synthesis of 6‐[ 18 F]fluoro‐ L ‐DOPA ([ 18 F]FDOPA). CDCl 3 , CD 2 Cl 2 and C 3 D 6 O were found to be suitable solvents in this reaction, with the deuterated solvents providing significantly higher yields than Freon‐11. There were no differences among the solvents in the specific radioactivity, the radiochemical purity, the chemical purity or the microbiological quality of the final product. However, the radiochemical yield of [ 18 F]FDOPA was increased when acetic acid was added to the precursor solution prior to the fluorination reaction. Copyright © 2009 John Wiley & Sons, Ltd.