Synthesis of [ 3 H]ABT‐518, a matrix metalloproteinase inhibitor (MMPI) labeled in the phenyl rings | Zendy

Raja Shirish N. | Zendy; Surber Bruce W. | Zendy; Du Jia | Zendy; Cross Jeffrey L. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of [ 3 H]ABT‐518, a matrix metalloproteinase inhibitor (MMPI) labeled in the phenyl rings

Author(s) -

Raja Shirish N.,

Surber Bruce W.,

Du Jia,

Cross Jeffrey L.

Publication year - 2009

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1574

Subject(s) - chemistry , yield (engineering) , benzene , matrix metalloproteinase inhibitor , sulfonyl , medicinal chemistry , stereochemistry , organic chemistry , enzyme , metallurgy , materials science , alkyl

A novel matrix metalloproteinase inhibitor, ABT‐518, [ S ‐( R * , R * )]‐ N ‐[1‐(2, 2‐dimethyl‐1,3‐dioxol‐4‐yl)‐2‐[[4‐[4‐(trifluoromethoxy)‐phenoxy]phenyl]sulfonyl]ethyl]‐ N ‐hydroxyformamide, was labeled with tritium in two phenyl rings in a seven‐step synthesis. The overall radiochemical yield of [ 3 H]ABT‐518 in seven steps starting from 1‐(methylsulfonyl)‐4‐[4‐(trifluoromethoxy)phenoxy]benzene was 6.2% with the radiochemical purity of 99.4%. Copyright © 2009 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research