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[5‐ 14 C]‐4‐methyltriazolepyridines via facile preparation of methyl‐[ 14 C]‐isothiocyanate
Author(s) -
Ström Peter,
Malmquist Jonas
Publication year - 2008
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1555
Subject(s) - chemistry , isothiocyanate , sulfur , one pot synthesis , organic chemistry , medicinal chemistry , catalysis
Abstract A fast and convenient microwave assisted one‐pot synthesis of methyl‐[ 14 C]‐isothiocyanate 4 was shown. The continued one‐pot synthesis with 4 to a highly refined material like [5‐ 14 C]‐dimethylsulfanyltriazolepyridines 8 and 13 without any intermediate purification, six steps in the same pot from [ 14 C]KCN. Oxidation of the sulfur provided access to triazole‐ethers upon reaction with alcohols. The triazole‐ethers, 15, were obtained at fair to good yields and specific activities above 2 GBq/mmol. Copyright © 2008 John Wiley & Sons, Ltd.