[5‐ 14 C]‐4‐methyltriazolepyridines via facile preparation of methyl‐[ 14 C]‐isothiocyanate

A fast and convenient microwave assisted one‐pot synthesis of methyl‐[ 14 C]‐isothiocyanate 4 was shown. The continued one‐pot synthesis with 4 to a highly refined material like [5‐ 14 C]‐dimethylsulfanyltriazolepyridines 8 and 13 without any intermediate purification, six steps in the same pot from [ 14 C]KCN. Oxidation of the sulfur provided access to triazole‐ethers upon reaction with alcohols. The triazole‐ethers, 15, were obtained at fair to good yields and specific activities above 2 GBq/mmol. Copyright © 2008 John Wiley & Sons, Ltd.