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An efficient synthesis of [ 13 C 6 ]‐3,5‐dichloroaniline
Author(s) -
Latli Bachir,
Hrapchak Matt,
Krishnamurthy Dhileepkumar,
Senanayake Chris H.
Publication year - 2008
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1521
Subject(s) - chemistry , aniline , hydrochloride , pharmacokinetics , chemical synthesis , salt (chemistry) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , pharmacology , in vitro , medicine
3,5‐Dichloroaniline is commonly found in many compounds with pharmacological and other biological activities. [ 13 C 6 ]‐Aniline or its hydrochloride salt was converted in three steps to [ 13 C 6 ]‐3,5‐dichloroaniline, which can be incorporated in compounds of interest and used as internal standards in drug metabolism and pharmacokinetics (DMPK) studies. Copyright © 2008 John Wiley & Sons, Ltd.
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