Syntheses of ( R , S )‐naproxen and its 6‐ O ‐desmethylated metabolite labelled with  2 H | Zendy

Fontana E. | Zendy; Venegoni S. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Syntheses of ( R , S )‐naproxen and its 6‐ O ‐desmethylated metabolite labelled with 2 H

Author(s) -

Fontana E.,

Venegoni S.

Publication year - 2008

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1511

Subject(s) - chemistry , metabolite , naproxen , demethylation , reagent , stereochemistry , chromatography , organic chemistry , biochemistry , medicine , gene expression , alternative medicine , pathology , dna methylation , gene

Naproxen, a well‐known non‐steroidal anti‐inflammatory drug, and its 6‐ O ‐desmethylated metabolite have been labelled with 2 H. ( R , S )‐Naproxen 7 labelled with 2 H was obtained in five steps using the commercially available [ 2 H 3 ]iodomethane 5 as the stable labelled reagent. The demethylation of 7 using 48% HBr in 1‐butyl‐3‐methylimidazolium tetrafluoborate gave the corresponding 2 H‐labelled 6‐ O ‐desmethylated metabolite 8. Copyright © 2008 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research