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Synthesis of deuterium‐labelled (−)‐galanthamine
Author(s) -
Rouleau Julien,
Guillou Catherine
Publication year - 2008
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1510
Subject(s) - chemistry , deuterium , methylation , stereochemistry , medicinal chemistry , biochemistry , physics , gene , quantum mechanics
The synthesis of deuterium‐labelled galanthamine is reported. 6‐[ 2 H 3 ]methoxy‐ N ‐[ 2 H 3 ]methyl‐(−)‐galanthamine was obtained in seven steps from galanthamine. The synthesis was carried out by selective O ‐ and N ‐demethylations. The [ 2 H 3 ]‐ N ‐methyl and [ 2 H 3 ]‐ O ‐methyl‐groups were introduced by selective aminoreduction and O ‐methylation. Copyright © 2008 John Wiley & Sons, Ltd.
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