Efficient synthesis of  13 C‐labelled erythromycin biosynthetic intermediate. 1:  S ‐2‐acetylaminoethyl (2 R ,3 R ,4 R ,5 R )‐3,5‐diacetoxy‐2,4‐dimethyl‐4‐([ 13 C]methoxy)‐heptanethioate | Zendy

Iida Katsumi | Zendy; Kajiwara Masahiro | Zendy; InoueTanihata Tomoko | Zendy; Fukui Mineo | Zendy; Nakata Tadashi | Zendy; Oishi Takeshi | Zendy

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Efficient synthesis of 13 C‐labelled erythromycin biosynthetic intermediate. 1: S ‐2‐acetylaminoethyl (2 R ,3 R ,4 R ,5 R )‐3,5‐diacetoxy‐2,4‐dimethyl‐4‐([ 13 C]methoxy)‐heptanethioate

Author(s) -

Iida Katsumi,

Kajiwara Masahiro,

InoueTanihata Tomoko,

Fukui Mineo,

Nakata Tadashi,

Oishi Takeshi

Publication year - 2008

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1507

Subject(s) - chemistry , erythromycin , biosynthesis , stereochemistry , elongation , labelling , antibiotics , biochemistry , enzyme , metallurgy , ultimate tensile strength , materials science

An efficient 13 C‐labelling synthesis of the putative erythromycin biosynthetic intermediate, S ‐2‐acetylaminoethyl (2 R ,3 R ,4 R ,5 R )‐3,5‐diacetoxy‐2,4‐dimethyl‐4‐([ 13 C]methoxy)heptanethioate, which would be useful for the investigation of the chain elongation mechanism in erythromycin biosynthesis, was achieved by utilizing iodo[ 13 C]methane and (2 S ,3 R ,4 R ,5 R )‐4‐hydroxy‐3,5‐ O ‐isopropylidene‐2,4‐dimethylheptanol, obtained in our previous studies on erythromycin A synthesis. Copyright © 2008 John Wiley & Sons, Ltd.

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