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New method for routine production of L‐[methyl‐ 11 C]methionine: in loop synthesis
Author(s) -
Gómez Vanessa,
Gispert Juan Domingo,
Amador Víctor,
Llop Jordi
Publication year - 2008
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1483
Subject(s) - chemistry , methionine , yield (engineering) , enantiomer , radiochemistry , high performance liquid chromatography , nuclear chemistry , enantiomeric excess , chromatography , stereochemistry , organic chemistry , catalysis , biochemistry , enantioselective synthesis , materials science , amino acid , metallurgy
A fast, clean and reproducible method for the manufacture of the radiotracer L‐[methyl‐ 11 C]methionine is reported. The reaction at room temperature of the non‐radioactive precursor L‐homocysteine (1 mg solution in ethanol/water 50/50) with [ 11 C]CH 3 I in an HPLC loop led to the formation of the desired radiotracer with a high radiochemical yield (38.4±4.1% end of synthesis) in a short production time (12 min). Radiochemical purity of the final radiotracer was 99.9±0.05%. Specific activities in the range 11–45 GBq/µmol were obtained. The presence of the undesired enantiomer (D‐[methyl‐ 11 C]methionine) was not detected in any of the cases. Copyright © 2008 John Wiley & Sons, Ltd.
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