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Synthesis of radiolabelled photolabile fusidic acid analogues
Author(s) -
Schou Søren Christian,
Riber Ditte,
GrueSørensen Gunnar
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1458
Subject(s) - chemistry , fusidic acid , tritium , stereochemistry , chemical synthesis , antibiotics , combinatorial chemistry , biochemistry , bacteria , in vitro , staphylococcus aureus , physics , biology , nuclear physics , genetics
Two analogues of the antibiotic fusidic acid with photolabile groups, 4‐azidophenyl and 4‐benzoylphenyl, were successfully labelled with tritium via Pd/C catalysed tritiation of unsaturated precursors. Specific activities of 36 and 44 Ci/mmol were obtained. Copyright © 2007 John Wiley & Sons, Ltd.