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Synthesis of carbon‐14‐labelled pyronaridine tetraphosphate
Author(s) -
Park Sang Hyun,
Pradeep Kannampalli,
Jang Seung Ho
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1456
Subject(s) - chemistry , biodistribution , high performance liquid chromatography , microwave irradiation , pharmacokinetics , chemical synthesis , radiochemistry , chromatography , microwave , nuclear chemistry , organic chemistry , pharmacology , catalysis , biochemistry , in vitro , physics , quantum mechanics , medicine
Pyronaridine tetraphosphate is an antimalarial drug which is currently being widely investigated for use in the chemotherapy of malaria. We synthesized carbon‐14‐labelled pyronaridine tetraphosphate ( 14 C‐PNDP, 5 ) by a classical method and also by a microwave irradiation technique for use in biodistribution studies and pharmacokinetic analysis. The application of microwave irradiation facilitated the use of high temperatures resulting in decreased reaction time and employed far less amount of the starting material when compared with the classical method. 14 C‐PNDP ( 5 ) thus synthesized had a chemical purity of >99% as determined by high‐performance liquid chromatography (HPLC) and a radiochemical purity of >99% as determined by radio‐HPLC. Copyright © 2007 John Wiley & Sons, Ltd.