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Synthesis of deuterated naproxens
Author(s) -
Gannett Peter M.,
Miller Laura,
Daft Jonathan,
Locuson Charles,
Tracy Timothy S.
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1451
Subject(s) - chemistry , propanoic acid , naproxen , deuterium , stereochemistry , ring (chemistry) , organic chemistry , medicine , physics , alternative medicine , pathology , quantum mechanics
A general scheme for the synthesis of ( S )‐6‐methoxy‐2‐propanoic acid (naproxen) deuterated on the naphthyl ring, methoxy group, or both, is described. The resulting labeled naproxen derivatives are useful probes for examining atypical kinetics displayed by cytochrome P450 2C9. Copyright © 2007 John Wiley & Sons, Ltd.