Synthesis of ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene | Zendy

Schweiger Lutz | Zendy; Craib Stuart | Zendy; Welch Andrew | Zendy; Smith Tim A. D. | Zendy

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Synthesis of ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene

Author(s) -

Schweiger Lutz,

Craib Stuart,

Welch Andrew,

Smith Tim A. D.

Publication year - 2007

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1439

Subject(s) - chemistry , radiosynthesis , yield (engineering) , trifluoromethanesulfonate , radiochemistry , nuclear chemistry , methylation , carbon 14 , medicinal chemistry , positron emission tomography , organic chemistry , nuclear medicine , catalysis , physics , nuclear physics , medicine , biochemistry , thermodynamics , gene

In this paper, we describe the radiosynthesis of the compound ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene was carried out via 11 C‐methylation of ( E )‐2‐(hydroxy)‐3′,4,5′‐trimethoxystilbene by using [ 11 C]methyl trifluoromethanesulfonate ([ 11 C]methyl triflate). ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene was obtained with a radiochemical purity greater than 95% in a 20 ± 2% decay‐corrected radiochemical yield, based upon [ 11 C]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1.9 ± 0.6 GBq/µmol at EOB. Copyright © 2007 John Wiley & Sons, Ltd.

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