Premium
Synthesis of ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene
Author(s) -
Schweiger Lutz,
Craib Stuart,
Welch Andrew,
Smith Tim A. D.
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1439
Subject(s) - chemistry , radiosynthesis , yield (engineering) , trifluoromethanesulfonate , radiochemistry , nuclear chemistry , methylation , carbon 14 , medicinal chemistry , positron emission tomography , organic chemistry , nuclear medicine , catalysis , physics , nuclear physics , medicine , biochemistry , thermodynamics , gene
In this paper, we describe the radiosynthesis of the compound ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene was carried out via 11 C‐methylation of ( E )‐2‐(hydroxy)‐3′,4,5′‐trimethoxystilbene by using [ 11 C]methyl trifluoromethanesulfonate ([ 11 C]methyl triflate). ( E )‐2,3′,4,5′‐tetramethoxy[2‐ 11 C]stilbene was obtained with a radiochemical purity greater than 95% in a 20 ± 2% decay‐corrected radiochemical yield, based upon [ 11 C]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1.9 ± 0.6 GBq/µmol at EOB. Copyright © 2007 John Wiley & Sons, Ltd.