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Preparation of [ 11 C]methyl nona‐fluorobutyl‐1‐sulfonate ([ 11 C]MeONf) and its use in the synthesis of [ 11 C]‐6‐OH‐BTA‐1
Author(s) -
Jolly Dean,
Lakhrissi Younes,
Kovacevic Miriam M.,
Chertkow Howard,
Schirrmacher Ralf
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1432
Subject(s) - chemistry , sulfonate , yield (engineering) , methylation , chemical synthesis , radiochemistry , combinatorial chemistry , organic chemistry , in vitro , biochemistry , sodium , materials science , metallurgy , gene
The rapid, simple and high‐yield synthesis of the extraordinarily reactive 11 C‐methylating agent, [ 11 C]methyl nona‐fluorobutyl‐1‐sulfonate ([ 11 C]MeONf), and its use in the synthesis of the promising β‐amyloid imaging agent, [ 11 C]‐6‐OH‐BTA‐1, is reported. In terms of radioactive methylation yields, [ 11 C]MeONf seems to surpass [ 11 C]methyl trifluoromethansulfonate ([ 11 C]MeOTf) as a methylating agent in this particular case giving the 11 C‐labelled compound in high‐preparative radiochemical yields between 27 and 29% EOS with a minimum formation of radioactive by‐products. Copyright © 2007 John Wiley & Sons, Ltd.