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Scrambling versus specific processes in gaseous organic ions during mass spectrometric fragmentation: elucidation of mechanistic origins by isotope labelling – an overview
Author(s) -
Kuck Dietmar
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1405
Subject(s) - chemistry , scrambling , fragmentation (computing) , labelling , deuterium , ion , isomerization , isotope , kinetic isotope effect , mass spectrometry , hydride , polyatomic ion , isotopic labeling , photochemistry , hydrogen , computational chemistry , radiochemistry , organic chemistry , chromatography , nuclear physics , philosophy , biochemistry , linguistics , physics , computer science , catalysis , operating system
The use of isotope labelling for the elucidation of mass spectrometric fragmentation mechanisms is demonstrated in various cases of different nature. The intermediacy of ion/neutral (I/N) complexes during fragmentation, being both analytically and fundamentally relevant, is discussed and studies on the regiospecific and irreversible intracomplex hydride transfer reactions within ‘designed’ deuterium‐labelled I/N complexes are reported. By contrast, several types of scrambling processes, being due to reversible isomerization reactions prior to mass spectrometric fragmentation, are presented, exemplifying complete and incomplete, progressive and composite scrambling in gaseous organic ions. Copyright © 2007 John Wiley & Sons, Ltd.