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Organic chemical reaction mechanisms clarified for deuterium‐ and carbon‐13‐labeled hydrocarbons
Author(s) -
Baldwin John E.
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1389
Subject(s) - chemistry , deuterium , kinetic isotope effect , computational chemistry , imperfect , organic chemistry , biochemical engineering , nuclear physics , physics , engineering , linguistics , philosophy
Questions bearing on just how organic chemical structures are converted to other compounds can be addressed in numerous ways through syntheses and studies of appropriately designed stable–isotope‐labeled analogs. Most of the examples in the present review summarize studies of various thermal isomerizations and fragmentations that have provided information on mechanistic details, determinations of reaction stereochemistry, tests for possible interventions of short‐lived reaction intermediates, and relevant checks of theory‐based predictions and rationalizations. Such work serves either to reinforce generally accepted conceptual constructs for posited reaction mechanisms or to prompt reinterpretations of imperfect mechanistic understandings, as the experimental findings may require. Copyright © 2007 John Wiley & Sons, Ltd.