Synthesis of [ 2 H 3 ]‐labelled sulfamethoxazole and its main urinary metabolites | Zendy

Heinkele Georg | Zendy; Mürdter Thomas E. | Zendy

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Synthesis of [ 2 H 3 ]‐labelled sulfamethoxazole and its main urinary metabolites

Author(s) -

Heinkele Georg,

Mürdter Thomas E.

Publication year - 2007

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1375

Subject(s) - chemistry , sulfamethoxazole , yield (engineering) , metabolite , medicinal chemistry , nuclear chemistry , radiochemistry , chromatography , biochemistry , antibiotics , materials science , metallurgy

Sulfamethoxazole was labelled at positions 3, 5, and 4′ by H/D exchange in a mixture of 5% 2 H 2 SO 4 and 95% 2 H 2 O (v/v) under reflux for 72h with good isotope incorporation and acceptable yield. Subsequently, [ 2 H 3 ]‐sulfamethoxazole‐ N 1 ‐glucuronide and [ 2 H 3 ]‐ N 4 ‐acetyl‐sulfamethoxazole were synthesized. Copyright © 2007 John Wiley & Sons, Ltd.

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