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Synthesis of 1‐[ 15 N]amino‐2‐propanol hydrochloride
Author(s) -
Iida Katsumi,
Ohtaka Kuniaki,
Kajiwara Masahiro
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1291
Subject(s) - chemistry , sodium borohydride , phthalimide , hydrochloride , propanol , yield (engineering) , potassium , hydrolysis , organic chemistry , medicinal chemistry , condensation , sodium , nuclear chemistry , methanol , catalysis , materials science , metallurgy , physics , thermodynamics
1‐[ 15 N]Amino‐2‐propanol hydrochloride ( 2 ) was synthesized in three steps, i.e. Gabriel condensation of potassium [ 15 N]phthalimide ( 3 ) with chloroacetone ( 4 ), reduction of the product ([ 15 N]phthalimidoacetone ( 5 )) with sodium borohydride, and hydrolysis in 33% total yield from the 15 N‐source. Copyright © 2007 John Wiley & Sons, Ltd.