Synthesis of 1‐[ 15 N]amino‐2‐propanol hydrochloride | Zendy

Iida Katsumi | Zendy; Ohtaka Kuniaki | Zendy; Kajiwara Masahiro | Zendy

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Synthesis of 1‐[ 15 N]amino‐2‐propanol hydrochloride

Author(s) -

Iida Katsumi,

Ohtaka Kuniaki,

Kajiwara Masahiro

Publication year - 2007

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1291

Subject(s) - chemistry , sodium borohydride , phthalimide , hydrochloride , propanol , yield (engineering) , potassium , hydrolysis , organic chemistry , medicinal chemistry , condensation , sodium , nuclear chemistry , methanol , catalysis , materials science , metallurgy , physics , thermodynamics

1‐[ 15 N]Amino‐2‐propanol hydrochloride ( 2 ) was synthesized in three steps, i.e. Gabriel condensation of potassium [ 15 N]phthalimide ( 3 ) with chloroacetone ( 4 ), reduction of the product ([ 15 N]phthalimidoacetone ( 5 )) with sodium borohydride, and hydrolysis in 33% total yield from the 15 N‐source. Copyright © 2007 John Wiley & Sons, Ltd.

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