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Radiotracers for a multi‐target approach to the diagnosis of Alzheimer's disease
Author(s) -
Mukherjee Jogeshwar,
Head Elizabeth,
Pichika Rama,
Easwaramoorthy Balasubramaniam,
Collins Daphne,
Chen Ines,
Wang Crystal S.,
Saigal Neil,
Trinidad Portia,
Kim Kathy,
Nguyen Vivien L.
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1266
Subject(s) - chemistry , receptor , neuroscience , alzheimer's disease , 5 ht receptor , serotonin , dopamine , amyloid (mycology) , genetically modified mouse , disease , transgene , psychology , medicine , biochemistry , inorganic chemistry , gene
Development of β ‐amyloid plaques and neurofibrillary tangles is the hallmark of Alzheimer's disease (AD) and progressively affects the overall functioning of the brain. Noninvasive imaging methods aiding early diagnosis will significantly improve benefits provided by treatments and possibly lead to prevention of AD. We report the development of PET radiotracer methods for β ‐amyloid plaques and tangles, nicotinic α 4 β 2 receptors, serotonin 5HT1A receptors, dopamine D2/D3 receptors and norepinephrine transporters for the study of AD. This multi‐target approach is currently being evaluated in AD transgenic mice models. Copyright © 2007 John Wiley & Sons, Ltd.