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Synthesis of deuterium‐labelled meloxicam and piroxicam
Author(s) -
Balssa Frédéric,
Bonnaire Yves
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1261
Subject(s) - chemistry , piroxicam , meloxicam , isotope dilution , deuterium , mass spectrometry , chromatography , qualitative analysis , radiochemistry , pharmacology , medicine , qualitative research , social science , physics , alternative medicine , pathology , quantum mechanics , sociology
Four step syntheses of deuterium‐labelled meloxicam and piroxicam from saccharin via selective CD 3 I alkylation are described. Labelled oxicams are of great interest for qualitative and/or quantitative isotope dilution‐mass spectrometry, coupled with liquid chromatography, currently performed in anti‐doping and forensic laboratories. Copyright © 2007 John Wiley & Sons, Ltd.

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