Synthesis of deuterium‐labelled meloxicam and piroxicam | Zendy

Balssa Frédéric | Zendy; Bonnaire Yves | Zendy

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Synthesis of deuterium‐labelled meloxicam and piroxicam

Author(s) -

Balssa Frédéric,

Bonnaire Yves

Publication year - 2007

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1261

Subject(s) - chemistry , piroxicam , meloxicam , isotope dilution , deuterium , mass spectrometry , chromatography , qualitative analysis , radiochemistry , pharmacology , medicine , qualitative research , social science , physics , alternative medicine , pathology , quantum mechanics , sociology

Four step syntheses of deuterium‐labelled meloxicam and piroxicam from saccharin via selective CD 3 I alkylation are described. Labelled oxicams are of great interest for qualitative and/or quantitative isotope dilution‐mass spectrometry, coupled with liquid chromatography, currently performed in anti‐doping and forensic laboratories. Copyright © 2007 John Wiley & Sons, Ltd.

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