New approaches for the synthesis of isotopically labelled guanidine‐derived amino acids and noradrenaline reuptake inhibitors | Zendy

Bischoff Roland | Zendy; Hamilton Deborah J. | Zendy; Jobson Nicola K. | Zendy; Sutherland Andrew | Zendy

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New approaches for the synthesis of isotopically labelled guanidine‐derived amino acids and noradrenaline reuptake inhibitors

Author(s) -

Bischoff Roland,

Hamilton Deborah J.,

Jobson Nicola K.,

Sutherland Andrew

Publication year - 2007

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1242

Subject(s) - chemistry , guanidine , reboxetine , diastereomer , amino acid , arginine , stereoselectivity , side chain , stereochemistry , reuptake inhibitor , organic chemistry , biochemistry , catalysis , serotonin , polymer , receptor

A new approach for the stereoselective synthesis of guanidine‐derived amino acids, L ‐arginine and (+)‐blastidic acid, has been devised which allows the selective incorporation of isotopic labels in both the side chain of the amino acid as well as the guanidine unit. A new asymmetric synthesis of the ( S , R )‐diastereomer of reboxetine, an antidepressant, has also been completed which allows the specific incorporation of radiolabelled iodine for SPECT imaging. Copyright © 2007 John Wiley & Sons, Ltd.

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