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Synthesis of carbon‐14 labeled dibutyltin dichloride
Author(s) -
Lewin Anita,
Jeffcoat Robert,
Berrang Bertold
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1219
Subject(s) - chemistry , barium carbonate , carbon 14 , bromide , carbon fibers , yield (engineering) , carbonate , barium , radiochemistry , lithium (medication) , organic chemistry , nuclear chemistry , inorganic chemistry , raw material , medicine , physics , materials science , quantum mechanics , composite number , metallurgy , composite material , endocrinology
This report describes the preparation of carbon‐14 labeled dibutyltin dichloride from carbon‐14 labeled barium carbonate in 30% overall radiochemical yield. The key steps were (a) the preparation of carbon‐14 labeled butyl bromide from carbon‐14 labeled barium carbonate via carbon‐14 labeled butyl mesylate, and (b) the direct preparation of tetrabutyltin by the lithium‐mediated reaction of dibutyltin dichloride with carbon‐14 labeled butyl bromide. Copyright © 2007 John Wiley & Sons, Ltd.