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Isotopic enrichment enhancement in metabonomic analysis of UPLC–MS data sets
Author(s) -
Athersuch Toby J.,
Nicholson Jeremy K.,
Wilson Ian D.
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1217
Subject(s) - chemistry , labelling , xenobiotic , drug metabolism , chromatography , endogeny , metabolism , high performance liquid chromatography , biochemistry , enzyme
Isotopic enrichment of compounds dosed in drug metabolism studies greatly enhances the spectroscopic differentiation of xenobiotic and endogenous metabolites. We show the application of 13 C 15 N labelling of a model drug (4‐cyanoaniline) as an aid to metabonomic studies of UPLC–MS‐generated metabolic data sets. Copyright © 2007 John Wiley & Sons, Ltd.
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