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H/D‐exchange reactions with hydride‐activated catalysts
Author(s) -
Derdau Volker,
Atzrodt Jens,
Holla Wolfgang
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1209
Subject(s) - chemistry , catalysis , hydride , combinatorial chemistry , hydrogenolysis , metalloid , deuterium , organic chemistry , hydrogen , metal , physics , quantum mechanics
A safe, user friendly and efficient method to provide high deuterium incorporation into a variety of organic substrates was developed. Systematic screening of catalysts and activators revealed that the activation of the Pd‐ or Rh‐catalyst by NaBD 4 is essential for the H/D exchange. The feasibility has been demonstrated by the successful application of this method to bi‐ and tricyclic aromatic compounds as well as chiral natural products like dextrorphan or drugs like formoterol. Copyright © 2007 John Wiley & Sons, Ltd.