Synthesis of the myoview™ ligand, [bisphosphinoethane‐1,2‐ 14 C]tetrofosmin | Zendy

Woolley Geoffrey T. | Zendy; Kitson Sean L. | Zendy; Gordon Reid R. | Zendy

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Synthesis of the myoview™ ligand, [bisphosphinoethane‐1,2‐ 14 C]tetrofosmin

Author(s) -

Woolley Geoffrey T.,

Kitson Sean L.,

Gordon Reid R.

Publication year - 2007

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1199

Subject(s) - radiosynthesis , chemistry , ligand (biochemistry) , yield (engineering) , combinatorial chemistry , radiochemistry , nuclear medicine , biochemistry , receptor , positron emission tomography , medicine , materials science , metallurgy

The carbon‐14 radiolabels in [bisphosphinoethane‐1,2‐ 14 C]tetrofosmin ligand were readily introduced by reacting 1,2‐dibromo[U‐ 14 C]ethane with bis(2‐ethoxyethyl)benzylphosphine ( 1 ). This was converted to the Myoview™ ligand in an overall yield of 45%. This radiosynthesis was important in obtaining marketing approval from the regulatory authorities and allowed Myoview™ to become one of the main heart imaging agents of today. Copyright © 2007 John Wiley & Sons, Ltd.

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