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SPECT imaging of the α4β2 nicotinic receptor using [5‐ 123 I]A85380
Author(s) -
Pimlott Sally L.,
Piggott Margaret,
Patterson James,
Cavanagh Jonathan,
Wyper David J.
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1192
Subject(s) - chemistry , tracer , in vivo , spect imaging , radiochemistry , nuclear medicine , ligand (biochemistry) , nicotinic agonist , medical physics , receptor , biochemistry , nuclear physics , physics , medicine , microbiology and biotechnology , biology
In order to image nAChR density in vivo in humans, [5‐ 123 I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐ 123 I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, in vitro validation in human post‐mortem tissue and some initial in vivo clinical studies using the ligand [5‐ 123/125 I]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed. Copyright © 2007 John Wiley & Sons, Ltd.