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Synthesis and analysis of [ 3 H] salmon calcitonin ([ 3 H]SMC021)
Author(s) -
Ciszewska Grazyna,
Allentoff Alban,
Wu Amy,
Ray Tapan
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1191
Subject(s) - chemistry , salmon calcitonin , calcitonin , tritium , radiochemistry , nuclear physics , medicine , physics
Tritium‐labelled salmon calcitonin was synthesized successfully through a 5 step peptide synthesis. LC‐MS performed on each step played an important role for in process control. For accuracy, Q‐TOF MS was used to determine the specific activity of tritiated salmon calcitonin ([ 3 H]SMC021) using the triple charged ion. Copyright © 2007 John Wiley & Sons, Ltd.