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Efficient and practical syntheses of a stable labelled form of the non‐narcotic analgesic, bicifadine and its metabolites
Author(s) -
Chen Zhengming,
Yang Ji,
Little Gillian,
Keats Andrew
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1171
Subject(s) - chemistry , bioanalysis , deuterium , analgesic , narcotic , combinatorial chemistry , chromatography , pharmacology , anesthesia , medicine , physics , quantum mechanics
Abstract An efficient and practical synthesis of deuterium‐labelled bicifadine, together with 3 deuterium‐labelled bicifadine metabolites, was developed. The levels of deuterium incorporation are high, and the products were used as internal standards in bioanalytical method development and clinical bioanalysis. Copyright © 2007 John Wiley & Sons, Ltd.