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Easy preparative scale syntheses of labelled xanthines: caffeine, theophylline and theobromine
Author(s) -
Balssa Frédéric,
Bonnaire Yves
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1154
Subject(s) - theobromine , chemistry , theophylline , caffeine , chromatography , mass spectrometry , isotope dilution , organic chemistry , pharmacology , medicine , endocrinology
Several easy preparative scale (0.5–1.5 g) syntheses of deuterium labelled caffeine, theophylline and theobromine are described. Some new selective syntheses of theophylline and theobromine have been developed. Labelled xanthines are of great interest in qualitative or quantitative isotope dilution‐mass spectrometry, coupled with gas or liquid chromatography, currently performed in anti‐doping and forensic laboratories. Copyright © 2007 John Wiley & Sons, Ltd.