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Preparation and biodistribution of novel 99m Tc(CO) 3 ‐CNR complexes for myocardial imaging
Author(s) -
Hao Guiyang,
Zang Jianying,
Liu Boli
Publication year - 2007
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1151
Subject(s) - lipophilicity , biodistribution , chemistry , ether , radiochemistry , stereochemistry , organic chemistry , biochemistry , in vitro
We evaluated lipophilicity and biodistribution of a series of 99m Tc(CO) 3 ‐ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99m Tc(CO) 3 ‐MIBI analogs were prepared and analyzed by radio‐HPLC, and their lipophilicity was determined. These new complexes could be bi‐ or tri‐substituted in specified pH conditions like 99m Tc(CO) 3 ‐MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [ 99m Tc(CO) 3 (MIBI) 3 ] + though their heart uptake was not so high. Among these complexes, [ 99m Tc(CO) 3 (EPI) 2 (OH 2 )] + showed higher target to non‐target ratios at 5 and 30 min post‐injection than that of [ 99m Tc(CO) 3 (MIBI) 3 ] + . Copyright © 2007 John Wiley & Sons, Ltd.