Synthesis of  3 H‐ and  2 H 4 ‐labelled versions of the hypoxia‐activated pre‐prodrug 2‐[(2‐bromoethyl)‐2,4‐dinitro‐6‐ [[[2‐(phosphonooxy)ethyl]amino]carbonyl]anilino]ethyl methanesulfonate (PR‐104) | Zendy

Atwell Graham J. | Zendy; Denny William A. | Zendy

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Synthesis of 3 H‐ and 2 H 4 ‐labelled versions of the hypoxia‐activated pre‐prodrug 2‐[(2‐bromoethyl)‐2,4‐dinitro‐6‐ [[[2‐(phosphonooxy)ethyl]amino]carbonyl]anilino]ethyl methanesulfonate (PR‐104)

Author(s) -

Atwell Graham J.,

Denny William A.

Publication year - 2007

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1147

Subject(s) - chemistry , prodrug , aldehyde , deuterium , ethanol , medicinal chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , physics , quantum mechanics

3 H‐ and 2 H 4 ‐versions of the hypoxia‐activated pre‐prodrug PR‐104 [2‐[(2‐bromoethyl)‐2,4‐dinitro‐6‐[[[2‐(phosphonooxy)ethyl]amino]carbonyl]anilino]ethyl methanesulfonate], labelled in the ethylcarboxamide side chain, have been prepared, respectively, by [ 3 H]NaBH 4 reduction of a precursor late stage aldehyde, and by late stage incorporation of deuterium with 2‐amino[1,1,2,2‐ 2 H 4 ]ethanol. Copyright © 2007 John Wiley & Sons, Ltd.

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