Preparation of deuterium‐labeled monounsaturated and saturated fatty acids for use as stable isotope metabolic tracers | Zendy

Crane Sheldon N. | Zendy; Bateman Kevin | Zendy; Gagne Sebastien | Zendy; Levesque JeanFrancois | Zendy

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Preparation of deuterium‐labeled monounsaturated and saturated fatty acids for use as stable isotope metabolic tracers

Author(s) -

Crane Sheldon N.,

Bateman Kevin,

Gagne Sebastien,

Levesque JeanFrancois

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1142

Subject(s) - chemistry , elaidic acid , stearic acid , deuterium , isotope , organic chemistry , oleic acid , stable isotope ratio , radiochemistry , fatty acid , chromatography , biochemistry , physics , quantum mechanics , linoleic acid

Synthetic routes adaptable to the preparation of a variety of d 7 ‐labeled monounsaturated and saturated fatty acids are reported. Using these reaction sequences, d 7 ‐oleic [18:1 (9c)], d 7 ‐elaidic [18:1 (9t)], and d 7 ‐stearic acid (18:0) were prepared for use in metabolism studies as stable isotope‐labeled tracers. Copyright © 2006 John Wiley & Sons, Ltd.

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