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Preparation of deuterium‐labeled monounsaturated and saturated fatty acids for use as stable isotope metabolic tracers
Author(s) -
Crane Sheldon N.,
Bateman Kevin,
Gagne Sebastien,
Levesque JeanFrancois
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1142
Subject(s) - chemistry , elaidic acid , stearic acid , deuterium , isotope , organic chemistry , oleic acid , stable isotope ratio , radiochemistry , fatty acid , chromatography , biochemistry , physics , quantum mechanics , linoleic acid
Synthetic routes adaptable to the preparation of a variety of d 7 ‐labeled monounsaturated and saturated fatty acids are reported. Using these reaction sequences, d 7 ‐oleic [18:1 (9c)], d 7 ‐elaidic [18:1 (9t)], and d 7 ‐stearic acid (18:0) were prepared for use in metabolism studies as stable isotope‐labeled tracers. Copyright © 2006 John Wiley & Sons, Ltd.