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A new method of [ 99m Tc]‐ciprofloxacin preparation and quality control
Author(s) -
RodríguezPuig Daniel,
Piera Carlos,
Fuster David,
Soriano Alex,
María Sierra José,
Rubí Sebastià,
Suades Joan
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1134
Subject(s) - chemistry , tartrate , tartaric acid , ciprofloxacin , ligand (biochemistry) , combinatorial chemistry , chromatography , inorganic chemistry , organic chemistry , biochemistry , receptor , citric acid , antibiotics
[ 99m Tc]‐ciprofloxacin is a useful radiopharmaceutical for the detection of osteoarticular prosthesis infection. We report a new preparation method based on the use of tartrate anion as an exchange ligand and tartaric acid as a source of tartrate. An improved quality control procedure is also reported that allows measuring the level of [ 99m Tc]‐tartrate present in the radiopharmaceutical preparation. Copyright © 2006 John Wiley & Sons, Ltd.