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Synthesis of 99m Tc‐labeled organo‐germanium nanoparticles and their in vivo study as a spleen imaging agent
Author(s) -
Park Sang Hyun,
Gwon Hui Jeong,
Shin Junhwa
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1133
Subject(s) - biodistribution , chemistry , spleen , mononuclear phagocyte system , nanoparticle , in vivo , radiochemistry , imaging agent , germanium , nuclear chemistry , nuclear medicine , in vitro , nanotechnology , pathology , biochemistry , organic chemistry , medicine , materials science , microbiology and biotechnology , silicon , biology
Abstract 99m Tc‐Labeled organo‐germanium nanoparticles ranging in size from 60 to 80 nm were newly developed for a spleen imaging agent. The radiolabeled nanoparticles were prepared with a high labeling efficiency (over 99%) and they also showed an excellent stability at room temperature for 6 h. The biodistribution data of the nanoparticles injected into rats via intravenous routes showed a notably higher accumulation in the spleen when compared to other reticuloendothelial system organs. Gamma image of the rabbits obtained after an intravenous injection of the nanoparticles revealed a localization of the radioactivity mainly in the spleen and the liver. Copyright © 2006 John Wiley & Sons, Ltd.