Synthesis of  99m Tc‐labeled organo‐germanium nanoparticles and their  in vivo  study as a spleen imaging agent | Zendy

Park Sang Hyun | Zendy; Gwon Hui Jeong | Zendy; Shin Junhwa | Zendy

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Synthesis of 99m Tc‐labeled organo‐germanium nanoparticles and their in vivo study as a spleen imaging agent

Author(s) -

Park Sang Hyun,

Gwon Hui Jeong,

Shin Junhwa

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1133

Subject(s) - biodistribution , chemistry , spleen , mononuclear phagocyte system , nanoparticle , in vivo , radiochemistry , imaging agent , germanium , nuclear chemistry , nuclear medicine , in vitro , nanotechnology , pathology , biochemistry , organic chemistry , medicine , materials science , microbiology and biotechnology , silicon , biology

99m Tc‐Labeled organo‐germanium nanoparticles ranging in size from 60 to 80 nm were newly developed for a spleen imaging agent. The radiolabeled nanoparticles were prepared with a high labeling efficiency (over 99%) and they also showed an excellent stability at room temperature for 6 h. The biodistribution data of the nanoparticles injected into rats via intravenous routes showed a notably higher accumulation in the spleen when compared to other reticuloendothelial system organs. Gamma image of the rabbits obtained after an intravenous injection of the nanoparticles revealed a localization of the radioactivity mainly in the spleen and the liver. Copyright © 2006 John Wiley & Sons, Ltd.

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