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Preparation of tritium‐labeled Silybin—a protectant for common liver diseases
Author(s) -
Lee D. Y. W.,
Zhang X.,
Ji X. S.
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1132
Subject(s) - silybum marianum , chemistry , milk thistle , tritium , silibinin , aldehyde , diastereomer , alcohol , stereochemistry , organic chemistry , pharmacology , traditional medicine , medicine , catalysis , physics , nuclear physics
Silymarin, the seed extract of milk thistle plant, Silybum marianum , has been used traditionally for the treatment of liver diseases and bile duct infection. Silybin 1 is the main bioactive components of silymarin, consisting a pair of diastereomers: Silybin A and Silybin B. In this article, we report the preparation of tritium‐labeled Silybin, which was accomplished by protection of Silybin as tritylated compound 2 and followed by oxidation of the primary alcohol to its corresponding aldehyde 3 . Subsequent reduction with NaB[ 3 H] 4 and deprotection of the trityl group provided the tritium‐labeled Silybin 4 . Copyright © 2006 John Wiley & Sons, Ltd.