Preparation of tritium‐labeled Silybin—a protectant for common liver diseases | Zendy

Lee D. Y. W. | Zendy; Zhang X. | Zendy; Ji X. S. | Zendy

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Preparation of tritium‐labeled Silybin—a protectant for common liver diseases

Author(s) -

Lee D. Y. W.,

Zhang X.,

Ji X. S.

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1132

Subject(s) - silybum marianum , chemistry , milk thistle , tritium , silibinin , aldehyde , diastereomer , alcohol , stereochemistry , organic chemistry , pharmacology , traditional medicine , medicine , catalysis , physics , nuclear physics

Silymarin, the seed extract of milk thistle plant, Silybum marianum , has been used traditionally for the treatment of liver diseases and bile duct infection. Silybin 1 is the main bioactive components of silymarin, consisting a pair of diastereomers: Silybin A and Silybin B. In this article, we report the preparation of tritium‐labeled Silybin, which was accomplished by protection of Silybin as tritylated compound 2 and followed by oxidation of the primary alcohol to its corresponding aldehyde 3 . Subsequent reduction with NaB[ 3 H] 4 and deprotection of the trityl group provided the tritium‐labeled Silybin 4 . Copyright © 2006 John Wiley & Sons, Ltd.

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