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Synthesis of isotopomers of dopamine labeled with deuterium or tritium
Author(s) -
Pająk M.,
Kańska M.
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1123
Subject(s) - isotopomers , chemistry , tritium , decarboxylation , dopamine , deuterium , kinetic isotope effect , tritiated water , stereochemistry , enzyme , radiochemistry , catalysis , biochemistry , organic chemistry , physics , quantum mechanics , neuroscience , molecule , nuclear physics , biology
The synthesis of four isotopomers of dopamine labeled with deuterium or tritium is reported. The ring labeled [2′,5′,6′‐ 2 H 3 ]‐, and [2′,5′,6′‐ 3 H 3 ]‐dopamine were obtained using acid catalyzed isotopic exchange between dopamine and heavy or tritiated water respectively. Two selectively labeled isotopomers, i.e. [1R‐ 2 H]‐, and [1R‐ 3 H]‐dopamine were synthesized by enzymatic decarboxylation of L ‐DOPA using the enzyme tyrosine decarboxylase (EC 4.1.1.25) from Streptococcus faecalis . Copyright © 2006 John Wiley & Sons, Ltd.