A simple and efficient synthesis of [3 α ‐ 3 H]5 α ‐androst‐16‐en‐3 β ‐ol | Zendy

Ren S. | Zendy; Hesk D. | Zendy; McNamara P. | Zendy; Koharski D. | Zendy

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A simple and efficient synthesis of [3 α ‐ 3 H]5 α ‐androst‐16‐en‐3 β ‐ol

Author(s) -

Ren S.,

Hesk D.,

McNamara P.,

Koharski D.

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1117

Subject(s) - chemistry , ketone , chemical synthesis , specific activity , radiochemistry , organic chemistry , stereochemistry , enzyme , biochemistry , in vitro

An efficient one step synthesis of [3 α ‐ 3 H]5 α ‐androst‐16‐en‐3 β ‐ol by NaBT 4 reduction of a ketone precursor is described. The specific activity of the product was 21.6 Ci/mmol with a radiochemical purity >99%. Synthesis of the precursor, 5 α ‐androst‐16‐en‐3‐one, from commercially available 5 α ‐androst‐16‐en‐3 α ‐ol is also presented. Copyright © 2006 John Wiley & Sons, Ltd.

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