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A simple and efficient synthesis of [3 α ‐ 3 H]5 α ‐androst‐16‐en‐3 β ‐ol
Author(s) -
Ren S.,
Hesk D.,
McNamara P.,
Koharski D.
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1117
Subject(s) - chemistry , ketone , chemical synthesis , specific activity , radiochemistry , organic chemistry , stereochemistry , enzyme , biochemistry , in vitro
An efficient one step synthesis of [3 α ‐ 3 H]5 α ‐androst‐16‐en‐3 β ‐ol by NaBT 4 reduction of a ketone precursor is described. The specific activity of the product was 21.6 Ci/mmol with a radiochemical purity >99%. Synthesis of the precursor, 5 α ‐androst‐16‐en‐3‐one, from commercially available 5 α ‐androst‐16‐en‐3 α ‐ol is also presented. Copyright © 2006 John Wiley & Sons, Ltd.