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An improved synthesis of isotope labeled 6‐hydroxychlorzoxazone
Author(s) -
Jian Zhigang,
Ray Tapan,
Wu Amy,
Jones Lawrence
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1113
Subject(s) - chemistry , yield (engineering) , chlorzoxazone , metabolite , benzene , radiochemistry , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , cyp2e1 , enzyme , cytochrome p450 , materials science , metallurgy
[ 13 C 6 ]6‐Hydroxychlorzoxazone, a major P450 metabolite of chlorzoxazone, was synthesized from [ 13 C 6 ]benzene in an overall 18% yield. An improved procedure for converting 4‐chloro‐6‐nitrosoresorcinol to 6‐hydroxychlorzoxazone was developed, with a yield more than double that previously reported in the literature. Copyright © 2006 John Wiley & Sons, Ltd.