An improved synthesis of isotope labeled 6‐hydroxychlorzoxazone | Zendy

Jian Zhigang | Zendy; Ray Tapan | Zendy; Wu Amy | Zendy; Jones Lawrence | Zendy

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An improved synthesis of isotope labeled 6‐hydroxychlorzoxazone

Author(s) -

Jian Zhigang,

Ray Tapan,

Wu Amy,

Jones Lawrence

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1113

Subject(s) - chemistry , yield (engineering) , chlorzoxazone , metabolite , benzene , radiochemistry , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , cyp2e1 , enzyme , cytochrome p450 , materials science , metallurgy

[ 13 C 6 ]6‐Hydroxychlorzoxazone, a major P450 metabolite of chlorzoxazone, was synthesized from [ 13 C 6 ]benzene in an overall 18% yield. An improved procedure for converting 4‐chloro‐6‐nitrosoresorcinol to 6‐hydroxychlorzoxazone was developed, with a yield more than double that previously reported in the literature. Copyright © 2006 John Wiley & Sons, Ltd.

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