Synthesis of deuterium labeled standards of 5‐methoxy‐ N , N ‐dimethyltryptamine (5‐Meo‐DMT) | Zendy

Xu YaZhu | Zendy; Chen Chinpiao | Zendy

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Synthesis of deuterium labeled standards of 5‐methoxy‐ N , N ‐dimethyltryptamine (5‐Meo‐DMT)

Author(s) -

Xu YaZhu,

Chen Chinpiao

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1109

Subject(s) - chemistry , dimethylamine , oxalyl chloride , yield (engineering) , lithium (medication) , indole test , aluminum hydride , chloride , medicinal chemistry , combinatorial chemistry , organic chemistry , methanol , medicine , materials science , metallurgy , endocrinology , methoxide

The Batcho‐Leimgruber strategy was employed to synthesize 5‐[ 2 H 3 ]‐methoxy‐1 H ‐indole 4 from commercially available 5‐hydroxy‐2‐nitrotoluene 1 and CD 3 I. Compound 4 was treated with oxalyl chloride, dimethylamine and lithium aluminum hydride to yield 5‐[ 2 H 3 ]‐methoxy‐ N , N ‐dimethyltryptamine 6 . Copyright © 2006 John Wiley & Sons, Ltd.

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