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Preparation of 31 Si‐labelled silicate: a radiotracer for silicon studies in biosystems
Author(s) -
Brasser H. J.,
Gürboǧa G.,
Kroon J. J.,
Kolar Z. I.,
Wolterbeek H. T.,
Volkers K. J.,
Krijger G. C.
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1096
Subject(s) - chemistry , radiochemistry , ion exchange , silicon , nuclear chemistry , specific activity , silicate , ion exchange resin , ion , inorganic chemistry , organic chemistry , enzyme
No‐carrier‐added 31 Si was produced by 31 P(n,p) 31 Si in the nuclear reactor of the Delft University of Technology. Several methods were investigated to remove the side product 32 P, and the chemical form of 31 Si was investigated. All methods except one gave good results. Anion exchange with Dowex resin gave the best results in activity concentration (3.8 × 10 6 Bq/ml, with only 3.2 × 10 3 Bq/ml 32 P as by‐product) and specific activity ( A s >17 TBq/g). The product is suitable for biological systems. Copyright © 2006 John Wiley & Sons, Ltd.