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Probing the regioselective C ‐deuteriation of lithium enolates derived from 2‐methyl‐tetralone in the presence of substituted tertiary amines
Author(s) -
Begum Mothia,
Chavda Sameer,
Coumbarides Gregory S.,
Dingan Marco,
Eames Jason,
Suggate Michael J.,
Weerasooriya Neluka
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1089
Subject(s) - chemistry , lithium (medication) , tetralone , regioselectivity , tertiary amine , tetralones , organic chemistry , stereochemistry , catalysis , medicine , endocrinology
Results are reported on the regioselective C ‐deuteriation of 2‐methyl‐tetralone using a series of D ‐sources and tertiary amines as potential mediators. The results presented further aid the understanding of kinetic deuteriation of both ‘base‐containing’ and ‘base‐free’ enolates. Copyright © 2006 John Wiley & Sons, Ltd.