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Investigations into the C ‐deuteriation of silyl enol ethers derived from aryl alkyl ketones
Author(s) -
Buksha Svitlana,
Coumbarides Gregory S.,
Dingjan Marco,
Eames Jason,
Suggate Michael J.,
Weerasooriya Neluka
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1088
Subject(s) - chemistry , enol , silylation , alkyl , regioselectivity , deuterium , aryl , medicinal chemistry , organic chemistry , catalysis , physics , quantum mechanics
Results are reported on the regioselective C ‐deuteriation of a series of silyl enol ethers derived from aryl alkyl ketones using deuterium (D 2 ) gas as the deuterium source and palladium‐on‐barium sulfate as the mediator. These results highlight the numerous reaction pathways and different product types available from simple deuteriation of substituted enol precursors. Copyright © 2006 John Wiley & Sons, Ltd.