Synthesis of isotopically labelled glycyl‐ L ‐prolyl‐ L ‐glutamic acid (Glypromate ® ) and derivatives | Zendy

Harris Paul W. R. | Zendy; Brimble Margaret A. | Zendy

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Synthesis of isotopically labelled glycyl‐ L ‐prolyl‐ L ‐glutamic acid (Glypromate ® ) and derivatives

Author(s) -

Harris Paul W. R.,

Brimble Margaret A.

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1075

Subject(s) - chemistry , glutamic acid , dipeptide , tripeptide , yield (engineering) , glycine , stereochemistry , deuterium , amino acid , biochemistry , materials science , physics , quantum mechanics , metallurgy

The related tripeptides glycyl‐ L ‐prolyl‐ L ‐glutamic acid (GPE) and glycyl‐ L ‐2‐methylprolyl‐ L ‐glutamic acid (G‐2‐MePE) were labelled with commercially available [1,2,3,4,5‐ 13 C 5 , 2‐ 15 N 1 ]‐ L ‐glutamic acid in 3 steps in excellent overall yield with high isotope incorporation. A related cyclic dipeptide was labelled with [2,2‐ 2 H 2 , 2‐ 15 N 1 ]glycine giving a mixture of compounds resulting from deuterium scrambling. Copyright © 2006 John Wiley & Sons, Ltd.

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